Can I Give My Cat Zofran?

Ask your vet first
Ondansetron is used in cats, but dosing decisions belong to your veterinarian. Used in cats for nausea from kidney disease and chemotherapy, prescription only. A vomiting cat needs a diagnosis before an anti-nausea drug.
Source: Veterinary Partner (VIN)
Get the exact range for your cat's weight

Skip it or ask a vet first if

liver disease (dose adjustment, vet)

The safe habit

Confirm any medication decision with your veterinarian, who knows your cat's health history and other medications. VetDose shows published reference data, not prescriptions.