Published dose range
The published veterinary reference range for same + milk thistle (silybin) in dogs is 18-20 mg per kg of body weight, given every 24h. In practice: SAMe ~18-20 mg/kg on empty stomach; combo products by label weight band.
Source: Veterinary Partner (VIN) →Liver-support standard. Give 1h before food. Elevated liver values still need vet workup, this supports, it does not diagnose.
If you think you overdosed
Call the Pet Poison Helpline: 855-764-7661 or ASPCA Poison Control: 888-426-4435. Both are staffed 24/7 by veterinary toxicologists.