Published dose range
The published veterinary reference range for same + milk thistle (silybin) in dogs is 18-20 mg per kg of body weight, given every 24h. In practice: SAMe ~18-20 mg/kg on empty stomach; combo products by label weight band.
Source: Veterinary Partner (VIN) →Published range by weight
| Weight | SAMe + milk thistle (silybin) (published range) |
|---|---|
| 5 lb dog | 41-45 mg |
| 10 lb dog | 82-91 mg |
| 20 lb dog | 163-181 mg |
| 30 lb dog | 245-272 mg |
| 40 lb dog | 327-363 mg |
| 50 lb dog | 408-454 mg |
| 60 lb dog | 490-544 mg |
| 80 lb dog | 653-726 mg |
| 100 lb dog | 816-907 mg |
Computed from the published 18-20 mg/kg reference range, every 24h. Product strengths rarely split evenly, so round DOWN to the nearest practical dose and confirm with your vet.
Liver-support standard. Give 1h before food. Elevated liver values still need vet workup, this supports, it does not diagnose.
If you think you overdosed
Call the Pet Poison Helpline: 855-764-7661 or ASPCA Poison Control: 888-426-4435. Both are staffed 24/7 by veterinary toxicologists.